Koeman has previously been critical of Ireland's handling of McCarthy, who has returned from previous global breaks having aggravated hamstring and groin injuries.
James seems to be getting a lot of injuries at Everton so I don't think we've anything to be anxious about in terms of how much we push James. I think they've more scientists involved than there needs to be.
McCarthy is not the only Everton star who will miss the clash with Brighton: Seamus Coleman, Aaron Lennon, Ross Barkley, Ramiro Funes Mori and Yannick Bolasie are all out of action with an array of injuries.
He said: "First of all I don't know what Keane said about the situation - and I'm not interested in his comments". I'm not interested in his comments. "That's good for him, that's good for us and let's hope he will be totally fit and available for next weekend". Whilst the Merseyside club invested over £100 million pounds on new players in the summer, the departure of striker Romelu Lukaku to Manchester United has left them short on goals up front, having scored four times so far in the top flight this season.
"We like to bring him back".
Everton manager Ronald Koeman has confirmed that midfielder James McCarthy has returned to full training but will miss his side's trip to face Brighton and Hove Albion along with the rest of the Toffees' long-term injury victims.
While Williams will try to shake off the disappointment of Wales' failure to reach the World Cup, Gylfi Sigurdsson returned buoyant after helping Iceland qualify. "It was a disappointing result against Burnley last time out so it's very important for us to start picking up points and it would be nice to do that on Sunday. But we have also players who haven't qualified".
He said: " I'm not surprised that they put my name in because they did the same some years ago.
"We have other business to do with Everton. That will then take us into the next couple of games on Thursday and Sunday".
Tomer Hemed serves the second game of his three match ban for violent conduct, with Steve Sidwell now the only long term absentee after undergoing minor back surgery last month.