Their form at Stamford Bridge however has been very inconsistent with a win, a draw and a loss for the season so far.
The two teams look well-matched ahead of the game, but Chelsea will need to find an answer to City's forwards, who are in prolific form, if they are to get anything out of the game.
The game also features one of the league's three joint highest scorers, new Chelsea striker Alvaro Morata, who is joined on six goals so far this season with City's Sergio Aguero - absent today after being involved in a vehicle crash in Amsterdam on Thursday - and Manchester United's Romelu Lukaku.
Both City and Chelsea, three points behind both Pep Guardiola's men and second-placed Manchester United, go into Saturday's game on the back of midweek Champions League victories over Shakhtar Donetsk and Atletico Madrid respectively.
City enters the contest the hotter of the two sides as they've won four straight.
David Luiz is still serving a domestic ban and the experienced Gary Cahill will likely be his replacement in this game.
Chelsea have experience with freakish down-time injuries.
The ankle injury that Pedro suffered against Arsenal wasn't as bad as originally feared and the Spanish winger will be available for selection this weekend.
Indeed, the 24-year-old scored a brilliant hat-trick in Chelsea's 4-0 win against Stoke City at the bet365 Stadium last weekend as the summer signing thrived at one of the league's toughest grounds. "I like to watch his game".
Guardiola did confirm Mendy will be unavailable for several months.
Chelsea's tenacity is in midfield where N'Golo Kante, Victor Moses, Willian, Cesc Fabregas and Alonso usually make it hard for teams that play a free style to maintain their fluidity. City have goals all over their squad, but none more important than those of Jesus. Compare this to City, who are best price of 19/10.
Antonio Conte has expressed confidence that Chelsea are in top shape, looking to get a favourable result against Manchester City at Stamford Bridge on Saturday. Man City had the slightly higher percentage heading into Wednesday's UCL games.
"We're going to prove that we are ready for that and hopefully it will be a great game for us".
Additionally, City's recent form against Chelsea at Stamford Bridge would suggest that Pep Guardiola's side will have their work cut out, especially considering that star winger Eden Hazard looks to have returned to full fitness after a lengthy lay off.
This could be a cracker but we'll take the champions to shade it, with Hazard 7/1 with Sun Bets to score first.
City travel to reigning champions Chelsea in today's evening kick-off (5:30pm) and there's plenty of discussion around what's already being dubbed a key game in the title race.