But Arsene Wenger's double change turned the game, FA Cup final hero Ramsey drilling in an 83rd-minute equaliser and Giroud notching the victor two minutes later with a header that hit the bar and bounced over the line.
"Overall I must say we kept going and the spirit of the team was absolutely outstanding and overall you could say as well we were punished on every single mistake tonight by a Leicester team who was very efficient going forward".
"He is an intelligent player who can integrate our game well as we have a game backed on mobility, technique. (We had) 70 percent possession, 27 shots on goal, Leicester had three shots on target and scored three so that shows you how efficient they are". Despite being held in the box, Giroud got up and powered a header just over the bar, unleashing a roar at the Emirates from fans who were expecting the worst as Leicester's lead carried on into the match.
Alexis Sanchez will miss Arsenal's opening two Premier League games through an abdominal injury. They have won only once in their last seven opening-day games - a 2-1 victory against Crystal Palace in 2014 - and have not lost three consecutive opening-day games since 1960.
Is he going to do the job of Shinji Okazaki?
"The first goal was from a short corner and we were not focused enough".
It was scruffy end to a sublime move in which Arsenal's players tippy-tapped their way through the Leicester defence with laser-like speed and precision. Granit Xhaka's sloppy pass was picked up by Albrighton and he forged down the left flank before bending a sublime cross into the danger area that Vardy converted.
Wenger also stated that lack of focus on the part of his defenders cost Arsenal the first two goals they conceded.
Leicester were out to make it a torrid night for Arsenal, though, as Vardy got his second off a corner kick to put the Foxes 3-2 ahead in the 55th minute. "One was a corner, one on build-up, one on a corner again", he said.
Cech, Holding, Monreal, Kolasinac; Bellerin, Elneny, Xhaka, Oxlade-Chamberlain; Ozil, Welbeck; Lacazette.